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Ceftin ® (Cefuroxime) belongs to a class of antibacterials called Cephalosporins which are used to treat infections in many different parts of the body, however these will not work for colds, flu, or other virus infections. . Cephalosporins are sometimes given with other antibiotics. Cephalosporins are also in injectable form to prevent infections before, during, and after surgery.

Ceftin ( Cefuroxime Axetil )


Ceftin ® is manufactured by Lifecycle Pharmaceuticals.

Chemical Name : Cefuroxime Axetil

 Important Note
The following information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effective for you. Consult your healthcare professional before using this drug.

Uses
Ceftin (Cefuroxime) is a Cephalosporin used in the treatment of infections caused by bacteria and works by killing bacteria and preventing their growth.

How to take this medication
Ceftin (Cefuroxime) may be taken on a full or empty stomach. If this medicine upsets your stomach, it may help to take it with food. To help clear up your infection completely, keep taking Ceftin (Cefuroxime) for the full time of treatment , even if you begin to feel better after a few days. If you have a “strep” infection, you should keep taking this medicine for at least 10 days. This is especially important in “strep” infections since serious heart or kidney problems could develop later if your infection is not cleared up completely. Also, if you stop taking this medicine too soon, your symptoms may return.

Usual dosage for Adults and teenagers is 250mg to 500mg every twelve hours while it is maximum of 250mg every 12 hours of children upto 12 years.

Side Effects
Every medicine can cause side effects, but many people have no, or minor, side effects. Common side effects include black, tarry stools; chest pain; chills; cough; fever; painful or difficult urination; shortness of breath; sore throat; sores, ulcers, or white spots on lips or in mouth; swollen glands; unusual bleeding or bruising (more common for cefamandole, cefoperazone, cefotetan and cefuroxime); unusual tiredness or weakness

Less common side effects include abdominal or stomach cramps and pain (severe); abdominal tenderness; diarrhea (watery and severe, which may also be bloody); hives or welts, itching redness of skin, or skin rash; pain, redness and swelling at site of injection; peeling of skin; seizures

Precautions
For patients with diabetes, Ceftin (Cefuroxime) may cause false test results with some urine sugar tests . Check with your doctor before changing your diet or the dosage of your diabetes medicine. Ceftin (Cefuroxime) may cause diarrhea. Do not take any diarrhea medicine without first checking with your doctor . Diarrhea medicines may make your diarrhea worse or make it last longer.

Overdose
If overdose is suspected, contact your local poison control center or emergency room immediately.

Missed Dose
If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not take a double dose to make up for a missed one.

Storage
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.

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 Beta-lactam-resistance patterns of some gram-negative rods

Antibiotic susceptibility to ampicillin of 290 E. coli, 56 Klebsiella sp. And 167 P.mirabilis strains was evaluated by the disk diffusion method. Data were interpreted according to the NCCLS criteria. 37.9% of E. coli, 85.7% of Klebsiella sp. And 65.9% of P. mirabilis strains were resistant to ampicillin. In all resistant to ampicillin strains were performed resistance patterns to following antibiotics: piperacillin, amoxicillin/clavulanic acid, cefoxitin, cefuroxime, ceftazidime, cefotaxime and imipenem. The strains resistant to ampicillin were divided into four groups depending on resistance patterns.

Cefuroxime Axetil (Ceftin), a new oral cephalosporin for treating infections of the ORL field: clinical synthesis

Cefuroxime Axetil (Ceftin) (C.A.E.) is a broad spectrum cephalosporin, suitable for oral route. Its antibacterial activity includes all the pathogens usually responsible for E.N.T. infection, with low M.I.C.'s: H. influenzae, S. pneumoniae, S. aureus, S. pyogene. The stability of the drug against betalactamases, especially those produced by H. influenzae, associated with good bio availability (50%) and tissue penetration (30%) account for the potent in vivo bactericidal activity and clinical efficacy of cefuroxime axetil (Ceftin). More than 1,000 patients had been enrolled in controlled clinical trials: the success rates yielded by C.A.E. were 98%, 96% and 91%, respectively for pharingitis/tonsilitis, otitis media and acute sinusitis. C.A.E. is at least as effective as amoxycillin/clavulanic acid and safety appears to be better.

Antimicrobial treatment of otitis media.

The major pathogens causing acute otitis media (AOM) are Streptococcus pneumoniae and Haemophilus influenzae, with Moraxella catarrhalis, Streptococcus pyogenes, and Staphylococcus aureus less frequently isolated. The same organisms and Staphylococcus epidermidis are found in chronic otitis media with effusion. In chronic suppurative otitis media, Pseudomonas aeruginosa and S aureus are most frequently found. Antimicrobial agents found to be most effective in treating AOM are amoxicillin, trimethoprimsulfamethoxazole, erythromycin-sulfisoxazole, amoxicillin-clavulanate, and cefaclor. Cefuroxime Axetil (Ceftin) and cefixime are alternatives for which there are less data. Currently, about 20% of AOM cases are caused by beta-lactamase-producing strains (usually H influenzae or M catarrhalis) that are resistant to amoxicillin, thus favoring the use of the other agents listed. Concentrations of antibiotics in middle ear infections range from 10% to 76% of peak serum levels for the listed agents and are higher in AOM than in chronic otitis media with effusion, emphasizing the importance of adequate dosing for successful treatment.

Use of cefuroxime axetil (Ceftin) in clinical practice

This study summarizes the actual recommendations for cefuroxime axetil (Ceftin) treatment in dermatology and general medicine. These include the well known clinical efficacies in therapy of upper and lower respiratory tract infections, genitourinary tract infections and skin and soft tissue infections, but also connective tissue diseases, such as morphea and SCLE. Though the immunomodulatory activity of the drug should be established by further controlled studies, there are some limited literature data, which show the modulatory effect of cefuroxime axetil (Ceftin) on the lymphocyte proliferation and the production of selected cytokines.

 

 

 

 

11th March 2010
antibiotics antibiotics antivirals & antibiotics